Combined Immunodeficiency in an Appaloosa Foal

The carrier prevalence of severe combined immunodeficiency, lavender foal syndrome and cerebellar abiotrophy in Arabian horses in South Africa.

REASONS FOR PERFORMING STUDY The carrier prevalence of severe combined immunodeficiency (SCID), lavender foal syndrome (LFS) and cerebellar abiotrophy (CA) in Arabian foals in South Africa was determined in order to quantify the potential impact of these conditions locally. Furthermore, the carrier prevalence of SCID prior to and following the introduction of a genetic test was compared to eval...

The prevalence of severe combined immunodeficiency, lavender foal syndrome and cerebellar abiotrophy in Arabian horses in South Africa

Foal immunodeficiency syndrome: carrier testing has markedly reduced disease incidence.

Foal immunodeficiency syndrome (FIS), a fatal autosomal recessive disease found in three breeds of horses, was first reported (in the Fell pony) in 1996, and it soon became apparent that significant numbers of syndrome foals were being born each year. In each FIS case, the foals are clinically normal at birth, but start to weaken at 2–8 weeks (Scholes and others 1998) as they develop profound a...

Severe combined immunodeficiency presented with septic arthritis: A case report

Severe combined immunodeficiency is a rare, fatal syndrome of diverse genetic cause in which there is combined absence of T-lymphocyte and B-lymphocyte function (and in many cases also natural killer, or NK lymphocyte function). These defects lead to extreme susceptibility to serious infections. Without intervention, the T and B-cell dysfunction usually results in severe infection and death in ...

Atresia Coli in an Arabian Foal

Atresia coli is a congenital defect that result in an inability to pass feces since birth. In the present study, type IIIa atresia coli (blind ends) was identified in a male Arabian foal with clinical signs of abdominal distension, colic, failure in defecation and depression. At necropsy, segmental agenesis affected left ventral and right dorsal colon. The dorsal right colons, transverse, small...